NIH Study Finds J&J Covid Vaccine Recipients Better To Get Pfizer or Moderna Booster


Pfizer-BioNTech Covid-19 vaccines at a nursing home in Worcester, PA, USA, Wednesday 25 August 2021.

Hannah Bayer | Bloomberg | Getty Images

Recipients of the Johnson & Johnson Covid-19 vaccine are better off getting a booster shot from Pfizer or Moderna, a long-awaited US study showed on Wednesday.

The National Institutes of Health’s study of “mixing and matching” Covid vaccines enrolled over 450 adults who received one of three regimens currently available in the United States: J&J, Moderna’s, or Pfizer. The study has not yet been peer-reviewed.


The volunteers were divided into groups and received an additional vaccine from their original vaccine or a booster from another company.

All combinations raised antibody levels, although the Pfizer and Moderna boosters seemed to work best. According to the study, people who received a booster dose of Moderna or Pfizer vaccines had four times more antibody responses than those who received an additional dose of J&J.

Research has shown that recipients of the original Moderna or Pfizer vaccines can easily change third doses; the results were about the same.

This is an evolving story. Please stay tuned.

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