More than 36,000 doses of Jynneos vaccine are in stock in the US.

According to the Department of Health and Human Services, there are more than 36,000 doses of Jynneos monkeypox vaccine in the United States that are immediately available in strategic national stockpiles.

The Centers for Disease Control and Prevention is sending the vaccine to people at high risk of contracting the virus to stop the disease from spreading further. As of Friday, there were 25 confirmed or suspected cases of monkeypox in the US in 12 states.

The US has informed Danish biotech company Bavarian Nordic to supply an additional 36,000 doses of Jynneos in the near future, an HHS spokesman said. The U.S. has more than 1 million doses, and could fill another 16.4 million doses at the request of the federal government, according to a Bavarian Nordic spokesperson.

The global monkeypox outbreak is the largest outside of Africa. The World Health Organization has reported nearly 800 confirmed cases of monkeypox in 27 countries. Most cases in Europe, especially in Portugal, Spain and the UK.

In 2019, the Food and Drug Administration approved Jynneos for adults 18 years of age and older with a high risk of smallpox or monkeypox. The two-dose vaccine is the only vaccine approved specifically to prevent monkeypox. However, the US also has more than 100 million doses of ACAM2000 old-generation smallpox vaccine, the spokesman said. ACAM2000 is manufactured by Emergent BioSolutions.

The US has distributed 1,200 doses of Jynneos and ACAM2000 to people at high risk of contracting monkeypox, Dr. Raj Punjabi, who heads the White House office for pandemic preparedness, said while speaking to reporters on Friday.

Although ACAM2000 was approved by the FDA in 2007 to prevent smallpox, the vaccine can also be used to protect against monkeypox under the CDC program. Monkeypox belongs to the same family of viruses as smallpox, although it is much milder.

The US is also distributing an oral antiviral drug called tecovirimat that can be used to treat people infected with monkeypox, Punjabi said. Tecovirimat was the first tablet approved by the FDA in 2018 for the treatment of smallpox, although it can also be used against monkeypox under the CDC program.

The CDC generally recommends Jynneos over ACAM2000, which can have serious side effects. ACAM2000 uses a live, weak strain of a virus from the same family as monkeypox and smallpox, which can still be transmitted in humans and other people. The vaccine is given as a single dose that is rubbed into the upper arm, after which the virus develops into a localized infection in the form of a blister.

The patient can spread the virus to other parts of the body if they scratch the blister and then, for example, rub their eyes, which can damage their eyesight. The virus can also spread to other members of the patient’s family, which can be dangerous if the family member has a weak immune system, is pregnant, or is breastfeeding. The FDA has warned that it is important for people receiving ACAM2000 to properly care for the injection site so as not to spread the virus.

There are also large groups of people who should not receive ACAM2000 as recommended by the CDC due to the risk of side effects. These people include pregnant or breastfeeding women, people with weak immune systems, people with skin conditions, and people with heart conditions.

In pregnant women, the vaccine strain can spread to the fetus and cause stillbirth. People with weak immune systems face the risk of the virus spreading uncontrollably, which can cause a dangerous infection. People with skin conditions such as eczema or atopic dermatitis are also at risk for the virus to spread through the skin and develop a life-threatening infection. ACAM2000 is also associated with a risk of heart inflammation known as myocarditis and pericarditis.

The Jynneos vaccine has fewer side effects because the vaccine uses a weak strain of the virus that cannot replicate in the human body and therefore cannot spread.

According to Mark Slifka, an immunologist at the Oregon Health and Science University, ACAM2000 has demonstrated high levels of protection against monkeypox in animal models and is expected to provide 85% protection against disease caused by the virus, similar to earlier versions of smallpox vaccines. Not much is known about the effectiveness of Jynneos because the vaccine is newer, but it produces good antibodies in humans and should protect against serious illness, Slifka said.

The global outbreak of monkeypox has raised public health concerns as the spread of the virus outside of West and Central Africa is unusual. Historically, the virus has been transmitted from rodents to humans in remote villages in Africa. However, according to Slifka, the virus is now better transmitted between people through close physical contact.

WHO officials said last week that the virus is likely to spread undetected outside of Africa for some time, although it is not clear for how long.

According to the WHO, most cases so far have been reported by gay and bisexual men who have developed systems and sought help from sexual health clinics. Health officials emphasize that anyone can contract monkeypox through close physical contact. However, they said it is important to raise awareness of the situation in the LGBT community so that people can protect their health.

Dr. Jennifer McQuiston, a spokesperson for the CDC, told reporters last week that the majority of US patients had traveled internationally 21 days before symptoms began, indicating they likely caught the virus abroad. While the CDC doesn’t think monkeypox is widespread in the US right now, public health can’t rule out the possibility that it’s domestically transmitted, McQuiston said.

Most people who contract monkeypox recover within two to four weeks without special treatment, McQuiston says, although the disease’s characteristic rash can be very painful. According to her, the threat to public health is now low.

Monkeypox usually starts with flu-like symptoms and then spreads throughout the body. The virus is mainly transmitted through skin contact with these rashes. People can also get monkeypox through shared sheets or clothing. People who have lesions in their throat or mouth can also spread the virus through the air, although according to the Centers for Disease Control and Prevention (CDC), the disease cannot be transmitted that way.

People with confirmed or suspected monkeypox infection should self-isolate at home until state or local health departments decide otherwise, according to the CDC. People with monkeypox should only come out of isolation after the rash has cleared up and a new layer of skin has formed.

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